Autoantibodies and thrombophilia in RA: TNF and TNF blockers

Do TNF-blockers reduce or induce uveitis?

Do TNF-blockers reduce or induce uveitis? SIR, Uveitis is a well-known manifestation of SpAs that may lead to functional impairment. TNF-blockers are effective for treating SpA-related uveitis flares [1], but recent retrospective studies support the possibility of differential TNF-blockers effectiveness, with infliximab or adalimumab showing a higher efficacy than etanercept in the treatment of...

CNS Demyelination with TNF-α Blockers

Tumor necrosis factor-α (TNF-α) blockers are a popular therapeutic choice in a number of inflammatory diseases. Thus far, five TNF- α blockers have been approved for clinical use (etanercept, infliximab, adalimumab, golimumab. and certolizumab). Despite being considered relatively safe, serious side effects associated with immune suppression have been reported, including central and peripheral ...

Unmet Needs in RA: The Role of Anti-TNF Therapy

Serum Levels of TNF-α, TNF-αRI, TNF-αRII and IL-12 in Treated Rheumatoid Arthritis Patients

Background: Rheumatoid arthritis (RA) is a chronic multisystem autoimmune disease common in all races and ethnics. Cytokines and cytokines receptors play an important role in RA pathogenesis and clinical presentation. Objective: To investigate the serum levels of TNF-α, TNF-α RI, TNF-α RII and IL-12 in RA patients and healthy control group. Methods: In this study 43 patients fulfilling the revi...

Anti-TNF failure and response to rituximab in seropositive and seronegative RA